Cardiovascular System - 11%

Dermatologic System - 4%

Endocrine System - 6%

Eyes, Ears, Nose, and Throat - 6%

Gastrointestinal System/Nutrition - 8%

Genitourinary System - 4%

Hematologic System - 5%

Infectious Diseases - 7%

Musculoskeletal System - 8%

Neurologic System - 7%

Psychiatry/Behavioral Science - 7%

Pulmonary System - 9%

Renal System - 5%

Reproductive System - 7%

Professional Practice* - 6%

History Taking and Performing Physical Examination - 16%

Using Diagnostic and Laboratory Studies - 10%

Formulating the Most Likely Diagnosis - 18%

Managing Patients Health Maintenance, Patient Education, and Preventive Measures - 11%

Clinical Intervention - 16%

Pharmaceutical Therapeutics - 15%

Applying Foundational Scientific Concepts - 8%

Professional Practice* - 6%

Cardiomyopathy

• Hypertrophic

• Restrictive

• Stress

Conduction disorders/dysrhythmias

• Atrial fibrillation

• Atrial flutter

• Atrial tachycardia

• Atrioventricular block

• Bradycardia

• Bundle branch block

• Idioventricular rhythm

• Junctional rhythms

• Premature contractions

• QT prolongation

• Sick sinus syndrome

• Sinus arrhythmia

• Torsades de pointes

• Ventricular fibrillation

• Ventricular tachycardia

Congenital heart disease ‍

• Atrial septal defect

• Coarctation of aorta

• Patent ductus arteriosus

• Patent foramen ovale

• Tetralogy of Fallot

• Transposition of the great vessels

• Ventricular septal defect

Coronary artery disease‍

• Acute coronary syndrome

o Angina pectoris

o Non–ST-segment elevation myocardial infarction

o ST-segment elevation myocardial infarction

o Unstable angina

• Atherosclerosis

Heart failure

Hypertension

• Primary hypertension

• Secondary hypertension

• Hypertensive emergencies

Hypotension

• Orthostatic hypotension

• Vasovagal hypotension

Lipid disorders

Shock

• Cardiogenic

• Distributive

• Hypovolemic

• Obstructive

Traumatic, infectious, and inflammatory heart conditions

• Cardiac tamponade

• Infective endocarditis

• Myocarditis

• Pericardial effusion

• Pericarditis

Valvular disorders

• Aortic

• Mitral

• Pulmonary

• Tricuspid

Vascular disease

• Aortic aneurysm/dissection

• Arterial embolism/thrombosis

• Arteriovenous malformation

• Deep venous thrombosis

• Giant cell arteritis

• Peripheral artery disease

• Phlebitis/thrombophlebitis

• Varicose veins

Acneiform eruptions

• Acne vulgaris

• Folliculitis

• Perioral dermatitis

• Rosacea

Desquamation

• Erythema multiforme

• Stevens-Johnson syndrome

• Toxic epidermal necrolysis

Diseases/disorders of the hair and nails

• Alopecia

• Onychomycosis

• Paronychia/felon

Envenomations and arthropod bite reactions Infectious diseases

• Bacterial

o Cellulitis

o Erysipelas

o Impetigo

• Fungal

o Candidiasis

o Dermatophyte infections

• Parasitic

o Lice

o Scabies

• Viral

o Condyloma acuminatum

o Exanthems

o Hand-foot-and-mouth disease

o Herpes simplex

o Molluscum contagiosum

o Varicella-zoster virus infections

o Verrucae

Keratotic disorders

• Actinic keratosis

• Seborrheic keratosis

Neoplasms

• Benign

• Malignant

• Premalignant

Papulosquamous disorders

• Atopic dermatitis

• Contact dermatitis

• Drug eruptions

• Eczema

• Lichen planus

• Pityriasis rosea

• Psoriasis

• Seborrheic dermatitis

Pigment disorders

• Melasma

• Vitiligo

Skin integrity

• Burns

• Lacerations

• Pressure injury

Vascular abnormalities

• Cherry angioma

• Hemangioma

• Purpura

• Stasis dermatitis

• Telangiectasia

Vesiculobullous disease

• Pemphigoid

• Pemphigus

Other dermatologic disorders

• Acanthosis nigricans

• Hidradenitis suppurativa

• Lipomas/epidermal inclusion cysts

• Photosensitivity reactions

• Pilonidal disease

• Urticaria

Adrenal disorders

• Cushing syndrome

• Pheochromocytoma

• Primary adrenal insufficiency

Diabetes mellitus

• Type 1

• Type 2

Hypogonadism

Metabolic syndrome

Neoplasms

• Multiple endocrine neoplasia

• Neoplastic syndrome

• Primary endocrine malignancy

Parathyroid disorders

• Hyperparathyroidism

• Hypoparathyroidism

Pituitary disorders

• Acromegaly/gigantism

• Cushing disease

• Diabetes insipidus

• Dwarfism

• Pituitary adenoma

• Prolactinoma

• SIADH

Thyroid disorders

• Goiter

• Hyperthyroidism

• Hypothyroidism

• Thyroid nodules

• Thyroiditis

Eye disorders

• Conjunctivitis

• Corneal disorders

o Cataract

o Corneal ulcer

o Infectious

o Keratitis

o Pterygium

• Inflammatory disorders

o Iritis

o Scleritis

o Uveitis

• Lacrimal disorders

o Dacryoadenitis

o Dacryocystitis

o Dacryostenosis

o Keratoconjunctivitis sicca

• Lid disorders

o Blepharitis

o Chalazion

o Ectropion

o Entropion

o Hordeolum

• Neuro-ophthalmologic disorders

o Nystagmus

o Optic neuritis

o Papilledema

• Orbital disorders

o Orbital cellulitis

o Periorbital cellulitis

• Retinal disorders

o Macular degeneration

o Retinal detachment

o Retinopathy

• Retinal vascular occlusion

• Vision abnormalities

o Amaurosis fugax

o Amblyopia

o Glaucoma

o Strabismus

o Presbyopia

Ear disorders

• External ear

o Cerumen impaction

o Otitis externa

• Inner ear

o Acoustic neuroma

o Dysfunction of eustachian tube

o Labyrinthitis

o Vertigo

• Middle ear

o Cholesteatoma

o Otitis media

o Otosclerosis

o Tympanic membrane perforation

• Hearing impairment

o Conductive

o Sensorineural

• Other abnormalities of the ear

o Mastoiditis

o Meniere disease

o Tinnitus

Foreign bodies of the eyes, ears, nose, and throat

Trauma of the eyes, ears, nose, and throat

• Barotrauma of the ear

• Blowout fracture

• Corneal abrasion

• Globe rupture

• Hyphema Neoplasms

• Benign

• Malignant Nose/sinus disorders

• Epistaxis

• Nasal polyps

• Rhinitis

• Sinusitis

Oropharyngeal disorders

• Infectious/inflammatory disorders

o Angioedema

o Aphthous ulcers

o Candidiasis

o Deep neck infection

o Dental abscess

o Dental caries

o Epiglottitis

o Gingivitis

o Laryngitis

o Peritonsillar abscess

o Pharyngitis

• Salivary disorders

o Parotitis

o Sialadenitis

• Other oropharyngeal disorders

o Leukoplakia

Biliary disorders

• Acute cholecystitis

• Chronic cholecystitis

• Cholangitis

• Cholelithiasis

Colorectal disorders

• Abscess/fistula

• Anal fissure

• Constipation

• Diverticular disease

• Fecal impaction/incontinence

• Hemorrhoids

• Ileus

• Inflammatory bowel disease

• Irritable bowel syndrome

• Ischemic bowel disease

• Obstruction

• Polyps

• Rectal prolapse

• Toxic megacolon

Diarrhea

Esophageal disorders

• Esophagitis

• Gastroesophageal reflux disease

• Mallory-Weiss tear

• Motility disorders

• Strictures

• Esophageal Varices

• Zenker diverticulum

Gastric disorders

• Gastritis

• Gastroparesis

• Peptic ulcer disease

• Pyloric stenosis

Gastrointestinal bleeding

Hepatic disorders

• Acute hepatitis

• Chronic hepatitis

• Cirrhosis

• Fatty liver

• Portal hypertension

Hernias

Hyperemesis

Ingestion of toxic substances or foreign bodies

Metabolic disorders

• Phenylketonuria

• Rickets

Neoplasms

• Benign

• Malignant

Nutrition

• Food allergies and food sensitivities

• Hypervitaminosis/hypovitaminosis

• Malabsorption

• Refeeding syndrome

Obesity

Pancreatic disorders

• Acute pancreatitis

• Chronic pancreatitis

Small intestine disorders

• Appendicitis

• Celiac disease

• Intussusception

• Obstruction

• Polyps

Benign prostatic hyperplasia

Bladder disorders

• Incontinence

• Overactive bladder

• Prolapse

Congenital and acquired abnormalities

• Cryptorchidism

• Peyronie disease

• Trauma

• Vesicoureteral reflux

Infectious disorders

• Cystitis

• Epididymitis

• Fournier gangrene

• Orchitis

• Prostatitis

• Pyelonephritis

• Urethritis

Neoplasms

• Bladder

• Penile

• Prostate

• Testicular

Nephrolithiasis/urolithiasis

Penile disorders

• Erectile dysfunction

• Hypospadias/epispadias

• Paraphimosis/phimosis

• Priapism Testicular disorders

• Hydrocele/varicocele

• Testicular torsion

Urethral disorders

• Prolapse

• Stricture

Autoimmune disorders

Coagulation disorders

• Clotting factor disorders

• Thrombocytopenias

Cytopenias

• Anemia

• Leukopenia

Cytoses

• Polycythemia

• Thrombocytosis

Hereditary disorders

• G6PD deficiency

• Hemochromatosis

• Sickle cell disease

• Thalassemia

Immunologic disorders

Neoplasms, premalignancies, and malignancies

• Acute lymphocytic leukemia

• Chronic lymphocytic leukemia

• Acute myelogenous leukemia

• Chronic myelogenous leukemia

• Lymphoma

• Multiple myeloma

• Myelodysplasia

Transfusion reaction

Bacterial diseases

• Bartonella

• Botulism

• Campylobacter jejuni infection

• Chancroid

• Chlamydia

• Cholera

• Clostridioides difficile infection

• Diphtheria

• Gonococcal infections

• Methicillin-resistant Staphylococcus aureus infections

• Rheumatic fever

• Rocky Mountain spotted fever

• Salmonellosis

• Shigellosis

• Tetanus

Fungal diseases

• Blastomycosis

• Candidiasis

• Coccidioidomycosis

• Cryptococcosis

• Histoplasmosis

• Pneumocystis

Mycobacterial diseases

• Atypical mycobacterial disease

• Tuberculosis

Parasitic diseases

• Amebiasis

• Giardiasis

• Helminth infestations

• Malaria

• Pinworms

• Toxoplasmosis

• Trichomoniasis

Perinatal transmission of disorders

• Congenital varicella

• Herpes simplex virus

• Human papillomavirus

• Zika virus

• Group B streptococcus

Prion diseases

Sepsis/systemic inflammatory response syndrome

Spirochetal diseases

• Lyme disease

• Syphilis

Viral diseases

• Coronavirus infections

• Cytomegalovirus infections

• Epstein-Barr virus infections

• Erythema infectiosum

• Herpes simplex virus infections

• HIV/AIDS

• Human papillomavirus infections

• Influenza

• Measles

• Mumps

• Polio

• Rabies

• Roseola

• Rubella

• Varicella-zoster virus infections

Chest/rib disorders

• Deformities

• Fractures

Compartment syndrome

Degenerative diseases

• Osteoarthritis

Infectious diseases

• Osteomyelitis

• Septic arthritis

Lower extremity disorders

• Avascular necrosis

• Developmental dysplasia

• Extensor mechanism injuries

• Fractures/dislocations

• Osgood-Schlatter disease

• Slipped capital femoral epiphysis

• Soft-tissue injuries

Neoplasms

• Benign

• Malignant

• Paget disease of bone

Rheumatologic disorders

• Connective tissue diseases

• Fibromyalgia

• Gout/pseudogout

• Juvenile rheumatoid arthritis

• Osteoporosis

• Polyarteritis nodosa

• Polymyalgia rheumatica

• Polymyositis

• Reactive arthritis

• Rheumatoid arthritis

• Sjögren syndrome

• Systemic lupus erythematosus

• Systemic sclerosis (scleroderma)

Spinal disorders

• Ankylosing spondylitis

• Herniated disk disease

• Kyphosis

• Scoliosis

• Spinal stenosis

• Spondylolisthesis

• Spondylolysis

• Sprain/strain

• Torticollis

• Trauma

Thoracic outlet syndrome

Upper extremity disorders

• Fractures/dislocations

• Soft-tissue injuries

Cerebrovascular disorders

• Arteriovenous malformation

• Cerebral aneurysm

• Coma

• Hydrocephalus

• Intracranial hemorrhage

• Stroke

• Syncope

• Transient ischemic attack

Closed head injuries

• Concussion

• Postconcussion syndrome

• Traumatic brain injury

Cranial nerve palsies

Encephalopathic disorders

Headaches

• Cluster headache

• Migraine

• Tension headache

Infectious disorders

• Encephalitis

• Meningitis

Movement disorders

• Essential tremor

• Huntington disease

• Parkinson disease

• Restless legs syndrome

• Tourette disorder

• Tardive dyskinesia

Neoplasms

• Benign

• Malignant

Nerve disorders

• Complex regional pain syndrome

• Guillain-Barré syndrome

• Mononeuropathies

• Peripheral neuropathies

Neurocognitive disorders

• Cognitive impairment

• Delirium

Neuromuscular disorders

• Cerebral palsy

• Multiple sclerosis

• Myasthenia gravis

Seizure disorders

• Focal seizures

• Generalized seizures

• Status epilepticus

Spinal cord syndromes

• Cauda equina syndrome

• Epidural abscess

• Spinal cord injuries

Abuse and neglect

• Child abuse

• Elder abuse

• Intimate partner violence

• Physical abuse

• Psychological abuse

• Sexual abuse

Anxiety disorders

• Generalized anxiety disorder

• Panic disorder

• Phobias

Bipolar and related disorders

Depressive disorders

• Major depressive disorder

• Persistent depressive disorder (dysthymia)

• Premenstrual dysphoric disorder

• Suicidal/homicidal behaviors

Disruptive, impulse-control, and conduct disorders

Dissociative disorders

Feeding and eating disorders

Human sexuality and gender dysphoria

Neurodevelopmental disorders

• Attention-deficit/hyperactivity disorder

• Autism spectrum disorder

Obsessive-compulsive and related disorders

Personality disorders

Psychogenic nonepileptic seizure

Schizophrenia spectrum and other psychotic disorders

Sleep-wake disorders

Somatic symptom and related disorders

Substance-related and addictive disorders

Trauma and stress related disorders

• Adjustment disorders

• Bereavement

• Post-traumatic stress disorder

Acute respiratory distress syndrome

Foreign body aspiration

Hyaline membrane disease

Infectious disorders

• Acute bronchiolitis

• Acute bronchitis

• Acute epiglottitis

• Croup

• Empyema

• Influenza

• Pertussis

• Pneumonias

o Bacterial

o Fungal

o HIV-related

o Viral

• Respiratory syncytial virus infection

• Tuberculosis

Neoplasms

• Benign

• Malignant

• Carcinoid tumors

Obesity hypoventilation syndrome

Obstructive pulmonary diseases

• Asthma

• Chronic obstructive pulmonary disease

• Cystic fibrosis

Pleural diseases

Pulmonary circulation

• Cor pulmonale

• Pulmonary edema

• Pulmonary embolism

• Pulmonary hypertension

Restrictive pulmonary diseases

• Idiopathic pulmonary fibrosis

• Pneumoconiosis

• Sarcoidosis

Sleep apnea

Acid-base disorders

Acute kidney injury and acute renal failure

• Intrinsic

• Prerenal

• Postrenal

Chronic kidney disease/end-stage renal disease

Congenital or structural renal disorders

• Horseshoe kidney

• Hydronephrosis

• Polycystic kidney disease

Electrolyte disorders

Fluid imbalances

Neoplasms

• Renal cell carcinoma

• Wilms tumor

Renovascular disease

Rhabdomyolysis

Breast disorders

• Abscess

• Fibroadenoma

• Fibrocystic changes

• Galactorrhea

• Gynecomastia

• Mastitis

Cervical disorders

• Cervicitis

• Dysplasia

Contraceptive methods

Human sexuality and gender identity

Infertility

Menopause

Menstrual disorders

Neoplasms of the breast and reproductive tract

• Benign

• Malignant

Ovarian disorders

• Cysts

• Polycystic ovary syndrome

• Torsion

Pelvic inflammatory disease

Pregnancy

• Abruptio placentae

• Breech presentation

• Cervical insufficiency

• Cesarean and operative delivery

• Classifications of abortion

• Ectopic pregnancy

• Fetal distress

• Gestational diabetes

• Gestational trophoblastic disease

• Hypertensive disorders of pregnancy

• Labor/delivery

• Multiple gestation

• Placenta previa

• Postnatal/postpartum care

• Postpartum hemorrhage

• Postpartum pituitary disorders

• Postpartum psychiatric disorders

• Preconception/prenatal care

• Prelabor rupture of membranes

• Rh incompatibility

• Shoulder dystocia

• Umbilical cord prolapse